منابع مشابه
H295R Steroidogenesis Assay
1. The OECD initiated a high-priority activity in 1998 to revise existing, and to develop new, Test Guidelines for the screening and testing of potential endocrine disrupting chemicals. The 2002 OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupting Chemicals comprises five levels, each level corresponding to a different level of biological complexity (1). The in vitro H29...
متن کاملBisphenol A disrupts steroidogenesis in human H295R cells.
There is increasing concern over the risk of environmentally relevant doses of bisphenol A (BPA) on human endocrine systems. Effects of BPA on steroidogenesis and the related molecular mechanisms were investigated in H295R human adenocarcinoma cells. This immortal cell line is unique in expressing all the enzymes of the steroidogenic pathways. The effects of BPA on steroidogenesis, 17β-estradio...
متن کاملIZA Discussion Paper No. 456
International Integration, Risk and the Welfare State How does international integration affect the welfare state? Does it call for a leaner or an expanded welfare state? International integration may affect the distortions caused by welfare state activities but also the risks motivating social insurance mechanisms. This paper addresses these potentially counteracting effects in a fully specifi...
متن کاملNovel trends in endocrine disruptor testing: the H295R Steroidogenesis Assay for identification of inducers and inhibitors of hormone production.
Over the past two decades, there has been increasing concern about the possible impacts of exposure to chemicals in the environment on endocrine and reproductive systems in humans and wildlife [1]. To address these concerns, national and international programs have been initiated to develop new guidelines for the screening and testing of potential endocrine-disrupting chemicals (EDCs) in verteb...
متن کاملModulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assay.
BACKGROUND, AIM, AND SCOPE The presence of a variety of pollutants in the aquatic environment that can potentially interfere with the production of sex steroid hormones in wildlife and humans has been of increasing concern. The aim of the present study was to investigate the effects of extracts from Hong Kong marine waters, and influents and effluents from wastewater treatment plants on steroid...
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ژورنال
عنوان ژورنال: OECD guidelines for the testing of chemicals
سال: 2023
ISSN: ['2074-5753']
DOI: https://doi.org/10.1787/9789264122642-en